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Transcellular solute and xenobiotic transport across the BBB is selectively controlled by the local influx and efflux transporters, including ATP-binding cassette (ABC), P-glycoprotein (P-gp, ABCB1), breast cancer resistance protein (ABCG2), multidrug resistance-associated proteins (ABCC) transporters, and solute carrier transporters (Stefano et al., 1995)
DPP4 is the enzyme that breaks down GLP-1, so by inhibiting DPP4, GLP-1 may hang around in the system longer
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