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Mechanically, tumor tissues tend to enhance their own antioxidant defenses in response to high levels of oxidative stress by up-regulating SLC7A11 expression, while SLC7A11-mediated synthesis of GSH acts as a defense against the cytotoxic effects of radiotherapy or certain drugs, which further reduces the sensitivity of tumor cells to treatment

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Standard treatments like semaglutide and tirzepatide deliver substantial clinical outcomes for the majority of patients

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