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Epidermal PIH may resolve better and faster than dermal PIH where melanin accumulates in long-lived melanophages [27]. Melasma is also a chronic acquired hypermelanosis which involves increased melanin levels in the epidermis and/or dermis [28,29,30]. It manifests as bilateral dark or grayish-brown macules, more particularly located on the face

10.1038/s41586-019-1707-0 18 DownsJ

Silencing LRRFIP1 significantly inhibited WAD in C3H10T1/2 cells and reduced differentiation biomarker expression

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