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10.1046/j.1365-2125.2003.01907.x 53 SterneJ.HernnM.ReevesB.SavoviJ.BerkmanN.ViswanathanM.et al (2016)

The Impact of a Single Day on Symptoms and the Misconception of B12 Storage B12 Excretion: You are correct that a significant portion of the injected hydroxocobalamin is excreted from the body within 48 hours

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You may have vitamin B12 deficiency because of pernicious anemia or other reasons, such as taking certain medications, having certain health conditions, or drinking heavily