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Synthesis of Glutathione Glutamate-cysteine ligase converts glutamate and cysteine into gamma-glutamylcysteine, and glutathione synthetase adds glycine to form glutathione (GSH)

The post-op infusion (within the first week) replenishes during the highest-demand recovery period

A small study showed that supplementation with cysteine and glycine fully restores glutathione synthesis 19 and may lower levels of oxidative stress

Overview of one-carbon metabolism The figure illustrates a biochemical pathway of one-carbon metabolism

(PubMed) Freudenheim JL

This digestive cleaving process is so effective that nearly all of the plain glutathione you would take by mouth would never make it into circulation