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Variability in Response : Individual variability in response to PYY or its analogs is not well characterized

Secondary endpoints from the trials include weight loss, improved blood pressure, and self-reported sleep disturbances

Temperature control directly preserves the biological activity of these peptide-based medications

Neurosci Res 55:352360 Jang H, Kim S, Kim H, Oh SH, Kwak SY, Joo HW, Lee SB, Jang WI, Park S, Shim S (2022) Metformin protects the intestinal barrier by activating goblet cell maturation and epithelial proliferation in radiation-induced enteropathy

Patients should work with their prescriber to titrate the medication dose appropriately and avoid excessively restrictive eating patterns

It also has been reported that GLP-1 prevents apoptosis of INS-1 cells in response to glucolipotoxicity or staurosporin through PI3K dependent pathway 20,21