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PE-22-28 raises seizure threshold concerns via TREK-1 blockade Evidence integrity : Dihexa has a retracted key publication

There was some slight intestinal issues, but it wasn't a big deal

Mol Cell Endocrinol 2020;518:111038.ArticlePubMedPMC 11

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While capsules can be administered by mouth to pigs, it was decided to introduce the capsule directly into the jejunum, since the gastric transit in the pig can be variable and of long duration, the pig stomach is more fermenting than that of a human, and the pH of the stomach is high, to the extent that enteric coating of the capsule may not give adequate protection

The placenta as a compensatory iodine storage organ