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Retatrutide hits three different receptor systems (GIP, GLP-1, and glucagon) instead of one or two

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Time to exhaustion on the treadmill increased significantly in the semaglutide group, matching near-lean control performance

[6] The practical dosing takeaway is subtle but important: if the mechanism is substantially about shifting gene-expression programs over hours, then a dosing model built purely around minute-scale plasma kinetics misunderstands the pharmacodynamics

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