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Preclinical studies showed preferential reduction of abdominal and visceral adipose tissue, suggesting favorable body composition changes even when total weight loss is moderate

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Phase 3 data shows Retatrutide producing 28.7% loss at 68 weeks compared to Tirzepatides 20.9% at 72 weeks

The TRIUMPH program includes multiple phase 3 trials, and one trial, TRIUMPH-Outcomes, is specifically designed to answer the question of whether retatrutide reduces major adverse cardiovascular events

They are orphan nuclear receptors that share structural homology with classical estrogen receptors