Diazoxide inhibits insulin secretion by opening ATP-sensitive potassium channels in pancreatic -cells, and is therefore expected to prevent the hypoglycaemia of late dumping syndrome
However, the physiological half-life of GLP-1 in circulation is very short (less than 2 min), which can be attributed to both rapid proteolytic cleavage of the amide bond of alanine at position 8 (Ala8) in the N-terminus by ubiquitous dipeptidyl peptidase IV (DPP-IV), which results in the removal of the two N-terminal amino acids leading to the formation of a truncated inactive form 10,11 and clearance by the kidney as well
doi:10.12688/f1000research.20510.1 Croce L, De Martinis L, Pinto S, et al
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It is used in conjunction with a balanced diet and exercise program to help control blood sugar levels when other medications have not been effective
