Using biochemical and genotype data from a previously published PCOS genome-wide association study and GEO database, SVM, RF, unsupervised hierarchical cluster analysis, and Gaussian mixed model (GMM) were performed to investigate the hypothesis that there were biologically reproducible phenotypic relevant subtypes of PCOS with subtype-specific genetic associations, regarding reproductive and metabolic PCOS subtypes, as well as hyperandrogenemia and non-hyperandrogenemia PCOS subtypes [29, 107]
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Further research suggests that HCG injections can increase the production of testosterone in men, thus it shows potential as a testosterone replacement therapy TRT
Additionally, metformin treatment shows higher abundance of Bifidobacterium which can stabilize the GI mucosa by increasing the production of gastric mucin
Accuracy of laparoscopy in the diagnosis of endometriosis: a systematic quantitative review
