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Targeting metabolism for lupus therapy

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The control is determined by ThDP-dependent biosynthesis and/or distribution of the neurotransmitter precursors acetyl-CoA and 2-oxoglutarate, formed upon the oxidation of the glycolytic product pyruvate in the TCA cycle (Figure 1)

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doi: 10.1021/pr500907d 61 LamegoIMarquesMPDuarteIFMartinsASOliveiraHGilAM

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This inconsistency could be due to the presence of distinct subgroups of schizophrenia with varying GSH-levels

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