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For weight management in people without diabetes, NICE recommends considering specific GLP-1 agonists (semaglutide 2.4mg or liraglutide 3mg) only in specialist weight management services, for individuals with a BMI 35 kg/m (or 32.5 kg/m for people from South Asian, Chinese, other Asian, Black African, or African-Caribbean backgrounds) who have weight-related comorbidities

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Blood pressure, lipid profile, and body weight all improved modestly, but not sufficiently to explain the full cardiovascular benefit

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GHK-Cu has well-documented topical bioavailability and is the basis of many cosmetic serums