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Clinical trials have demonstrated that semaglutide can produce substantial weight losstypically 1015% of initial body weight over 68 weekswhen combined with lifestyle interventions including dietary modification and increased physical activity

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Jall S, Sachs S, Clemmensen C et al (2017) Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice

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