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With regard to distribution , for drugs such as diazepam 1 and penfluridol 5 that are substantially distributed into adipose tissue, greater adiposity is associated with greater storage of the drug in lipid reservoirs, and hence greater availability of the drug for return to blood as blood levels fall due to metabolism

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Hormonal balance plays a significant role in lupus disease activity

Just the fact that RA is well known to convey markedly increased risk for cardiovascular disease stands as testament