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doi: 10.1016/j.jconrel.2025.113841

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The Nrf2KEAP1 pathway stands as a master regulator of this balance, transcriptionally activating genes involved in GSH biosynthesis (GCLC, GCLM, GSR, and GSS), iron metabolism (FTL, FTH1, FPN1, and HO-1), and redox defense (SLC7A11, GPX4, and NQO1)all of which directly modulate ferroptosis susceptibility (283, 284)

It is also used in other cellular processes, most notably as a substrate of enzymes in adding or removing chemical groups to or from proteins, in posttranslational modifications