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Although numerous topical and systemic therapeutic agents and also non-pharmacologic procedural treatments have been considered in melasma management, however, the commonly available therapeutic options have several limitations including the lack of sufficient clinical effectiveness, risk of relapse, and high rate of unwanted adverse drug reactions

Al-Zubaidi U, Adhikari D, Cinar O, et al

It's not clear yet which of the many chemicals in coffee is responsible for the benefits

It's really important to chat with a healthcare provider

Sakamoto et al., 2017

TLR4) and other innate immune sensors in peripheral tissues and the brain [35, 36]