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A 2024 Diabetes, Obesity and Metabolism study on a small-molecule NNMT inhibitor found it dose-dependently limited body weight and fat mass gains, improved oral glucose tolerance and insulin sensitivity, and suppressed hyperinsulinaemia in obese mice (PMID 39161060) [6]

Some researchers hypothesize that the increased energy expenditure from glucagon activation means less of the caloric deficit needs to come from dietary restriction, which may be less catabolic to muscle tissue

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