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Supplementation with DHA/EPA may reduce amyloid burden, mitigate tau pathology, and improve memory in animal and early-phase clinical studies ( 1.3.4 Transitional metal ions Dysregulation of essential trace metals particularly iron (Fe), copper (Cu), and zinc (Zn) is increasingly recognized in AD pathophysiology

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The activation of NLRP3 is mediated by the nuclear factor kappa B (NF-B) signaling pathway that matures interleukin-1 (IL-1) and interleukin-18 (IL-18) into proinflammatory cytokines, serving as biomarkers of low-grade inflammation [13]

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Using NADPH as an electron donor, it breaks the disulfide bond of GSSG and reduces it to two GSH molecules, thereby maintaining a high GSH/GSSG ratio within the cell