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Monitor portion sizes At the end of the day, weight gain comes down to calories consumed versus calories burned

Yet they are still a minority pursuit

The glucagon component is thought to enhance thermogenesis the body's heat-generating metabolic processes potentially contributing to fat loss beyond what GLP-1 and GIP agonism alone can achieve

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This risk appears to be particularly high in individuals who have already been diagnosed with diabetic retinopathy or other underlying eye conditions

The STEP 4 trial showed that patients who stopped semaglutide after successful weight loss regained approximately two-thirds of their lost weight within one year