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Besides improving glucose control, reducing body weight, and lowering arterial blood pressure (surrogate endpoints), the breakthroughs were the demonstration of a significant reduction in cardiovascular and renal events in patients with type 2 diabetes at high risk

Liraglutide, semaglutide, and tirzepatide are all GLP-1 agonists resulting in significant weight loss in RCTs

Ethics declarations Conflict of Interest The authors declare that they have no conflict of interest

CGI/C, Clinical Global Impression-Change

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(Clipper team members have stressed that the probe will likely have to get lucky to pull off a sampling run, however, given that Europa's plume activity isn't well characterized and appears to be sporadic.) Those apparent big plumes may have smaller cousins, which are emanating from a source just below the surface, according to the new research