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12,13 While certain genetic disorders (eg, Kallmann syndrome) are linked to impaired function of the hypothalamus or pituitary gland from birth, toxic exposures and other environmental factors, both in utero and later in life, are also known to interfere with the activities of the gonadotropic hormones

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Patch Testing: For topical research, conducting a patch test on a small, inconspicuous area of skin (e.g., the inner forearm) is always a recommended step to assess individual skin compatibility before broader application