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NMDA receptor antagonists, such as memantine, are already in clinical use for the treatment of Alzheimer's disease, where they help reduce excitotoxic damage and improve cognitive function

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Low-level glucagon receptor engagement nudges the body to oxidise fat and may raise resting energy expenditure modestly

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It enhances neurotrophic factor expression, supports neural progenitor cell survival, and modulates microglial phenotypes for an anti-inflammatory state, promoting neural repair and regeneration [81]