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Numerous investigational therapies targeting inflammation, oxidative stress, liver regeneration, bile acid signalling, epigenetic regulation, and the gut-liver axis have been evaluated, with largely disappointing results

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Dopaminergic neurons in the substantia nigra , the brain region most affected by Parkinson's disease, express receptors for an inflammatory cytokine called tumor necrosis factor-alpha (TNF-) , which suggests that excess TNF- released by nearby activated microglia may damage nigral dopaminergic cells

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Synthesis of compound Ru(II)-OH The diiodo(p-cymene)ruthenium(II) dimer (54.8 mg, 0.05 mmol) was dissolved in methanol (20 mL) under 40 C