If using adjunctive treatments, either metformin or topiramate are good options for weight loss that may also benefit metabolic parameters (glucose/insulin, lipids) or symptoms, respectively.
Randomized controlled trials demonstrate that increased potassium intake, mostly in the form of potassium chloride supplementation, has a modest blood pressure lowering effect in those with normal or high blood pressure
Enrollment in Medicare Part D is required to participate in the demonstration.
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Meaningful weight reduction is generally observed by weeks 12 to 16, with maximum weight loss tending to occur later in the treatment period, depending on the agent and dose