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Men in the highest tirzepatide dose group lost an average of 22.5% of their starting weight, with cardiovascular risk markers improving significantly including reductions in blood pressure, triglycerides, and inflammatory markers

Phase III trials of semaglutide showed that nausea and appetite changes typically emerged by week one, peaked around days five to fourteen, and substantially improved by week four in most participants

The funding sources contributed to the design and conduct of the trial, the analysis and interpretation of the data, review and approval of the manuscript

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It treats food as part of the GLP-1 journey, not a separate diet project