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The New York Times, Christina Jewett

It is plausible, though untested, that targeted modulation of GLP-1R activity could maximize the beneficial effects of GLP-1 while minimizing potential adverse effects, particularly in conditions involving metabolic dysfunction, cardiovascular health, or other age-associated pathologies

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The importance of brain-derived GLP-1, the direct vs indirect actions of GLP-1 and GLP-1-induced control of neural activity is extensively discussed since many organs and cellular targets of GLP-1 action do not exhibit detectable levels of GLP-1R [20,21,22,23]

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