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Exendin-4 induces bone marrow stromal cells migration through bone marrow-Derived macrophages polarization via PKA-STAT3 signaling pathway

Clinical studies have demonstrated that GLP-1 receptor agonists can reduce various inflammatory biomarkers , including: C-reactive protein (CRP) : A general marker of systemic inflammation Interleukin-6 (IL-6) : A pro-inflammatory cytokine Tumour necrosis factor-alpha (TNF-) : Another key inflammatory mediator Plasminogen activator inhibitor-1 (PAI-1) : Associated with cardiovascular inflammation The magnitude of these effects varies between studies and may depend on baseline inflammatory status, degree of weight loss achieved, and individual patient characteristics

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GLP-1RAs have shown to improve cardiovascular health by decreasing blood pressure, stimulate differentiation of nerve cells and inhibit neuroinflammation, and inhibit hepatitis (7)

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In addition, both dual GLP-1/glucagon receptor agonists and triple GLP-1/GIP/glucagon receptor agonists are under thorough research