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Serious side effects are rare but can include hormonal imbalance (especially in women with PCOS or PCOD) and severe allergic reactions

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Indeed, RTA 408 administration has been coupled with inhibition of the ROS producing enzyme NADPH oxidase (NOX) using 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF) in the same kainite-induced SE model as above

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Landmark studies have shown that damaged mitochondria are cleared from the cell through the coordinated activity of the serine/threonine (Ser/Thr) kinase PINK1 and the ubiquitin E3 ligase Parkin (Figure 2)