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According to StatPearls (NCBI Bookshelf), the most common adverse effect of intramuscular vitamin B12 injections is significant pain at the injection site, which is particularly noted in thinner individuals
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Also, its deficiency can result in high levels of homocysteine in the blood which may have direct effects on the neurotransmitters implicated in depression
At the same time, those affected with Crohns often undergo surgeries that involve the removal of at least a portion of the terminal ileum, placing them at further risk for a vitamin B12 deficiency
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