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After reconstitution Reconstituted tirzepatide solution should be stored in the refrigerator at 2 to 8 degrees Celsius and typically remains stable for 7 to 28 days, depending on the diluent used and the concentration achieved
Even brief exposure to room temperature accelerates degradation
There are two major drivers of GLP-1 discontinuation in typical care: tolerability issues and insufficient behavioral support
For example, athletes with high muscle mass may have a high BMI but low body fat, while someone with a normal BMI could still have excess visceral fat
Among adults aged 65 and older, however, reported effectiveness is much lower, at 48%