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Contrarily, miR-148a has been linked to abrogation of epithelial-mesenchymal transition (EMT), which plays a critical role in cancer invasion and metastasis, at the same time that it exerts a suppressive role in pancreatic cancer cells invasion by targeting Wnt10b and inhibiting the Wnt/-catenin signaling pathway [47]

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33 It is thereby safe to say on the basis of published data, that absorption from the orobuccal route, for example by using oral dispersible film, is over 80% greater as compared to absorption from the gastrointestinal tract