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JamesSJCutlerPMelnykSJerniganSJanakLGaylorDWet al

The stability and potency of acylated GLP-1 RAs depends on the site of acylation, the bulkiness and length of the fatty acid chains, and the spacer used between the peptide and fatty acid [62-64], Because the N-terminus is key for receptor binding and activation, acylation in the N-terminal region leads to serious loss of potency

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Finally, gene inactivation of tumor suppressor NRF2 makes cancer cells in orthotopic malignant mesothelioma mouse models more sensitive to ferroptosis