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Review article: Endpoints used in functional dyspepsia drug therapy trials

The endogenous ligand was finally identified in 1999 by Kojima and colleagues: ghrelin, a 28-amino-acid peptide produced mainly by the stomach

The spin label MTSL (S-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl methanesulfonothioate) was conjugated to a single cysteine at position 1254 near the N-terminus of the 21mer S tail (Supplementary Table S1)

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