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Patients with mood disorders consistently had lower levels of Faecalibacterium and greater levels of Actinobacteria and Enterobacteriaceae (75)

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However, under electrophilic or oxidative stress, KEAP1 changes its structure and NRF2 dissociates from the complex, accumulates in the nucleus and induces the expression of its target genes involved in the antioxidant response, detoxification, metabolism and inflammation [11]

Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Variation Analysis (GSVA) analysis revealed significant activation of the glutathione metabolism pathway in drug-resistant breast cancer tissues compared to sensitive tissues after FEC (5-Fluorouracil, Epirubicin, and Cyclophosphamide) + docetaxel treatment (Fig