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Nausea, vomiting and digestive complaints arise from the slowed gastric emptying and the strengthened satiety signal

2007, pp

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The metabolic events most closely associated with AD include insulin resistance, hyperglycemia, lipid dysregulation, mitochondrial dysfunction, and oxidative stress

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Together, these preclinical findings strongly indicate that ferroptosis is not a secondary consequence of neurodegeneration in AD, but rather functions as an upstream pathogenic mechanism that drives A production, tau hyperphosphorylation, and neuronal apoptosis