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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations AEP: auditory evoked potential EEG: electroencephalograph GSH: glutathione NAC: N -acetyl-cysteine MMN: mismatch negativity NMDA: N -methyl-D-aspartate References Aydin S, Ozaras R, Uzun H, Belce A, Uslu E, Tahan V et al (2002)

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GLP-1 receptor agonists have well-characterized safety profiles based on extensive use in diabetes and obesity management, but specific considerations apply when considering their use in patients with substance use disorders

The GAG composition is altered, reducing hydration and resilience

Funding This study was supported by grants from the Singapore National Medical Research Council (CS-IRG, HLCA2022, STaR, OF LCG 000207), a clinical translational research programme in Parkinsons disease and a Duke-Duke-NUS collaboration pilot grant

The mean change in the Kansas City Cardiomyopathy Questionnaire clinical summary score was 16.6 points with semaglutide versus 8.7 with placebo, the mean body weight change was 13.3% versus 2.6%, and the 6-minute walk distance improved by 21.5 m versus 1.2 m