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Very mild or subclinical hypothyroidism with no significant symptoms In cases of subclinical hypothyroidism, where the TSH is slightly elevated but free T4 remains normal, and the patient has minimal or no symptoms, GLP-1 therapy may be started if there is a strong clinical indication such as prediabetes, elevated waist circumference, or high cardiovascular risk

Adems, el tratamiento con semaglutida increment las concentraciones de insulina en ayuno comparadas con placebo

Orforglipron is another drug in the pipeline, demonstrating activity only as a GLP-1 agonist

Kravchenko, O

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10.1038/s41467-022-35716-1 3 AvrahamiD.KlochendlerA.DorY.GlaserB