e-pub ahead of print 8 April 2018 (2018)
Amador-Arjona A, Cimadamore F, Huang CT, Wright R, Lewis S, Gage FH, et al
GLP-1 treatment can attenuate abnormal autophagy induced by ROS and inflammation through upregulating HDAC6 via the GLP-1R-ERK1/2 pathway [150]
CLINICALLY STUDIED INGREDIENTS FOR DIGESTIVE SUPPORT: Made with 10 billion active probiotic cultures, including Lactobacillus and Bifidobacterium strains, along with chicory root prebiotics, Keystone postbiotics, and Setria glutathione to support the gut microbiome
This stem cell recovering effect is particularly relevant to age-related hair thinning, where the follicle stem cell pool becomes depleted or quiescent over time
However, current evidence is still inconclusive to demonstrate a direct negative effect of GLP-1 RAs on LBM loss, largely due to heterogeneity in study designs and the limited number of trials specifically evaluating this endpoint [77]