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40-50 aos: Combinacin de tratamientos: rellenos, toxina botulnica, hilos tensores, bioestimuladores, tratamientos con dispositivos (radiofrecuencia, ultrasonidos)

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After 10-fold cross-validation by 1,000-time alteration, a risk signature including RRM1, GSR, GCLM, IDH2, RRM2, ODC1, GGT5, OPLAH and GSTZ1 was finally adopted