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A healthy, unstressed cell maintains a vast majority of its glutathione pool in the reduced state, typically sustaining a GSH-to-GSSG ratio of greater than 10:1, and often up to 100:1 in the cytosol
Although these studies often focus on adverse drug reactions or occupational exposures rather than environmental exposures directly, they nevertheless provide important evidence regarding the toxicological profiles of pharmaceutical compounds [39]
PMID: 2155033 DOI: 10.1016/S0006-3495(90)82574-1 Crumb WJ Jr, Clarkson CW (1992): Characterization of the sodium channel blocking properties of the major metabolites of cocaine in single cardiac myocytes
Hess, J., Keiser, J
Dietary Reference Intakes: The Essential Guide to Nutrient Requirements
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