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In PDPN, these mechanisms facilitate ectopic neuronal activity and enhance response to sensory stimuli

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These proteins, in turn, may induce apoptosis of old cells, thereby reducing the old cell burden in tissues

The nature of the experiences of the animals that develop increased MR expression with the related regulation of mGlu2 receptors is not known but might involve epigenetic experiences early in life, such as maternal care and stressors in the neonatal nesting environment

H2O2, although not a free radical itself, can generate highly reactive hydroxyl radicals (OH) via Fenton reactions in the presence of transition metals like iron and copper [45]