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Oxidative stress and neuronal loss Ferroptosis, an iron-dependent form of cell death distinct from apoptosis and necrosis, is primarily triggered by oxidative stress, a key pathological process in AD

doi: 10.2217/bmm-2020-0308 7 QiXMWangJXuXXLiYYWuYG

[DOI] [PubMed] [Google Scholar] [73].Chrissobolis S, Didion SP, Kinzenbaw DA, Schrader LI, Dayal S, Lentz SR, Faraci FM, Glutathione peroxidase-1 plays a major role in protecting against angiotensin II-induced vascular dysfunction

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Additionally, it causes defects in acrosome reaction, which prevent sperm penetrating the oolemma

It is expressed on the cell surface of various cell types including endothelial and immune cells and in tissues like the liver and kidney