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However, due to high out-of-pocket costs, drug shortages, and the fact that a prescription is needed to obtain these medications, people might be searching for other options

This can lead to unnecessary dose escalation that causes problems when you eventually switch to a fresh, full-potency vial

This article will explore their roles and differences and explain whether combining the two could offer greater benefits

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Physiology of the incretins GLP1 The two main incretin hormones are glucagon like peptide -1 (GLP-1) and gastric inhibitory peptides (GIP)

Clinical trials show tirzepatide produces greater weight loss (up to 22% body weight) than semaglutide (1518%), but semaglutide is often preferred first-line due to longer market history and lower cost