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This selectivity makes it a valuable research tool for investigating GHS-R1a-mediated signaling pathways, receptor activation kinetics, and ligand-receptor interactions without the broader receptor activity observed with less selective secretagogues

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Several studies confirmed the integrity of GH-signaling via GHR/JAK2/STAT5 pathway in the kidney by using renal cell lines [11, 12]

However, the effective dosage range is from 10 mg to 16.5 mg/mL

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