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Although the modulation of GRK2 levels inside the -cell upon non-genetic IR conditions is still to be characterized, it is tempting to postulate that a potential upregulation of GRK2 could impinge on both early and late events modulated by the GLP-1R during disease progression

The analysis, which included several of the above-mentioned, demonstrated a 14% reduction in the relative risk (RR) of MACE with GLP-1 RAs compared to placebo (87)

In animal experiments on such drugs, studies on rodents have found that the GLP-1RAs may promote the development of medullary thyroid carcinoma, but this effect has not been observed in non-human primates [23]

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Recent phase 2 and phase 3 clinical trials have established the therapeutic value of various GLP-1 RAs in improving liver histology and metabolic parameters in patients with MASH