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Structural analysis demonstrates how FOXO4-DRI exploits the unique architecture of senescent cells, where FOXO4 latches onto p53 and prevents it from executing its normal pro-apoptotic function

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The ALA/DHLA redox couple, fully satisfying these parameters, can be dened as an excellent antioxidant

In Parkinson disease models, microglia drive neuroinflammation via JNK/AKT/NF-B signaling 42 , and lipopolysaccharide activates inflammation in macrophages through the JNK/p-P65 pathway 43

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Its free-base form, although less common, exhibits increased volatility and solubility in organic solvents