Caffeine can increase the effects and toxicity of clozapine
Protein first
Avoiding high-fat and high-fiber foods immediately after dosing day allows the stomach to process meals more easily without triggering symptoms
Seek urgent medical attention as follows: Call 999 or go immediately to A&E if you experience: Sudden severe or thunderclap headache, confusion, difficulty speaking, seizures, or vision problems (especially if taking pseudoephedrine) Signs of anaphylaxis: difficulty breathing or swallowing, sudden swelling of lips/tongue/throat, collapse or loss of consciousness Severe chest pain or severe shortness of breath Contact your GP urgently (same day) or call NHS 111 if you experience: Blood pressure readings consistently above 180/120 mmHg, particularly if accompanied by symptoms such as severe headache, visual disturbance, chest pain, or shortness of breath (NICE NG136 guidance) Persistent severe headache with visual disturbances Palpitations or chest discomfort after starting a new allergy medication Rash, swelling, or other signs of allergic reaction to a new medication Symptoms suggesting sinusitis complications such as high fever, severe facial pain or swelling, or swelling around the eyes Regular monitoring is essential when managing both conditions
Cell 157 , 12921308 (2014)
Skin changes and temperature dysregulation leading to loss of turgor, dryness and therefore itching and surface breaks are common in cirrhosis and the use of moisturizers to improve hydration and maintain barrier integrity is always the first step toward reducing pruritus (4)
