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Combination Weight Loss (CagriSema) Extensive Research The Phase 3 REDEFINE 1 trial demonstrated that CagriSema (cagrilintide 2.4 mg plus semaglutide 2.4 mg) produced mean weight loss of 20.4% at 68 weeks in 3,417 adults with obesity or overweight without diabetes, compared to 14.9% with semaglutide alone, 11.5% with cagrilintide alone, and 3.0% with placebo

TRIUMPH-1 Primary Results (80 Weeks) TRIUMPH-1: 104-Week Extension In a prespecified extension for participants with BMI 35, average weight loss reached 30.3% at 104 weeks

Abbreviations: DM desmoplastic melanoma IHC immunohistochemisty MM malignant melanoma MPNST malignant periopheral nerve sheath tumor References [1] Uong A, Zon LI

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