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Therapeutic effects diminish progressively during this washout period as drug concentrations decline

But there is a critical caveat

Discontinue use and consult your healthcare provider if you notice any adverse effects

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In addition, in global health statistics, CKD has gradually become an important cause of death worldwide, affecting 15-20% of adults worldwide, and is often associated with diabetes, hypertension, cardiovascular disease and other chronic diseases (Jankowski et al., 2021

Why Weight Loss Maintenance Is Difficult